GHRP-2 10mg

Description

10mg of Lyophilized product in a 3ml vial

This product needs to be reconstituted before use

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and one of the ghrelin mimetics that stimulates the secretion of growth hormone (GH) by acting on the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a). It is under investigation for its potential applications in diagnosing and treating growth hormone deficiency, enhancing growth hormone secretion, and other therapeutic areas related to GH physiology.

Chemical Composition and Structure

• Chemical Name: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
• Structure: GHRP-2 is a synthetic hexapeptide composed of two amino acids, designed to mimic the endogenous growth hormone-releasing peptides (GHRPs) and ghrelin.

Mechanism of Action

GHRP-2 exerts its effects by binding to the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons. This binding initiates a signaling cascade that ultimately leads to increased secretion of growth hormone.

• GHS-R1a Activation: GHRP-2 binds to GHS-R1a, a G-protein coupled receptor (GPCR), activating the phospholipase C (PLC) pathway.
• Intracellular Signaling: Activation of the PLC pathway increases intracellular calcium concentrations and stimulates the release of growth hormone-releasing hormone (GHRH) and inhibits somatostatin (a GH-inhibitory hormone) in the hypothalamus.
• GH Secretion: The combined effects of increased GHRH and decreased somatostatin levels lead to a significant increase in GH secretion from the pituitary gland.

Clinical Applications

GHRP-2 is being researched for its potential use in several medical conditions and diagnostic applications:

• Growth Hormone Deficiency (GHD): GHRP-2 can be used to stimulate GH secretion in individuals with GHD, aiding in the diagnosis and treatment of this condition.
• Aging: GHRP-2 is investigated for its potential to counteract the decline in GH secretion associated with aging, potentially improving muscle mass, bone density, and overall quality of life in elderly individuals.
• Cachexia and Muscle Wasting: By enhancing GH secretion, GHRP-2 may help to mitigate muscle wasting in conditions such as chronic obstructive pulmonary disease (COPD), cancer, and HIV/AIDS.
• Metabolic Disorders: GHRP-2’s role in GH secretion may also have therapeutic implications for metabolic disorders, including obesity and metabolic syndrome, by improving body composition and insulin sensitivity.

Research and Development

Ongoing clinical trials are evaluating the safety, efficacy, and optimal dosing of GHRP-2 for its various proposed indications. Early studies have shown promising results, particularly in the context of GH deficiency and aging-related GH decline. Further research is needed to fully understand the long-term effects and potential applications of this peptide.

Pharmacokinetics

• Administration: GHRP-2 is typically administered via subcutaneous or intravenous injection.
• Absorption and Distribution: After administration, GHRP-2 is rapidly absorbed and distributed throughout the body, targeting GHS-R1a receptors in the pituitary and hypothalamus.
• Metabolism and Excretion: The peptide is metabolized by proteolytic enzymes and excreted primarily via the kidneys.

Safety and Tolerability

GHRP-2 has been generally well-tolerated in clinical trials, with the most common adverse effects being transient and mild, including headaches, flushing, and increased appetite. Long-term safety data are still being collected, and ongoing studies aim to further characterize the risk-benefit profile of this peptide.

Conclusion

GHRP-2 (Growth Hormone Releasing Peptide-2) is a promising research product with potential applications in diagnosing and treating growth hormone deficiency, addressing age-related declines in GH secretion, and treating conditions associated with muscle wasting and metabolic disorders. Its ability to stimulate GH secretion through activation of the GHS-R1a receptor offers a novel therapeutic approach. Further research and clinical trials will help to establish its efficacy, safety, and broader applications in medicine.

GHRP-2 is intended for research or lab use only and is not approved for any form of in vivo use. Please read and adhere to our terms and conditions before ordering.